Mega Man agrees to retrieve the stolen parts from the eight Robot Masters. Mega Man saves Wily from crashing and Wily says that Roboenza-infected robots attacked his spaceship and stole the parts to a medicine-making machine he had been working on to cure the virus. Light's lab with his capsule damaged and asks for help. One month after the outbreak, several infected robots become berserk and attempt to take over the world. Roll becomes infected with the virus, and the situation becomes worse as time passes and a cure is not found. In the year 20XX, an outbreak of a robotic-virus known as the ' Roboenza' ( ロボットエンザ, Robottoenza ) runs rampant across the globe, infecting and disabling robots, hampering daily life for humans. With the closure of the Wii Shop Channel, the purchase of Mega Man 10 and all DLC on Nintendo's Wii system and the Wii U (via backwards compatibility) was officially discontinued on January 30, 2019. It was announced by Nintendo Power in Decemand was released in March 2010 for the WiiWare service, Xbox Live Arcade, and PlayStation Network. Like its predecessor, Mega Man 9, it is a downloadable title and is based on the look and feel of the early NES titles.

Mega Man 10, known as Rockman 10: Uchū kara no Kyōi!! ( ロックマン10 宇宙からの脅威！！, Rokkuman 10 Uchū kara no Kyōi!!, which means, 'Rockman 10: Threat From Outer Space!!') in Japan, is a game from the original Mega Man series. For articles titled Mega Man X, see Mega Man X.

This article is about the 10th game in the original Mega Man series.

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